Indole-3-Carbinol Indole-3-Methanol

Model NO.
Indole-3-carbinol
Other Name 1
Indole-3-Methanol
Appearance
White or off-White Crystalline Powder
Other Name 2
3-Hydroxymethylindole
CAS No.
700-06-1
Product Name
Indole-3-Carbinol
Transport Package
25kgs/Fiber Drum
Specification
More than 98%
Trademark
JX Nutra
Origin
China
HS Code
2933990099
Production Capacity
5mt/Month
Reference Price
$ 82.80 - 94.50
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Product Description

Product name: Indole-3-carbinol 98%
CAS:700-06-1
Other names:  3-Indolylcarbinol; 1H-Indole-3-methanol; 3-Hydroxymethylindole; 3-Indolemethanol; Indole-3-methanol; I3C , indol 3 Karbinol
Molecular Formula: C9H9NO
Molecular Weight: 147.17
Storage: Store in a well closed dry place with constant low temperature  ( 2~  8ºC)  and no direct sun light .

Indole-3-Carbinol Indole-3-Methanol

Specification Sheet:
ITEM SPECIFICATION STANDARD














Physical 		Appearance White or Off-white Crystalline powder Visual
Loss on drying ≤ 2 .0 0 % Rapid moisture analyzer
Reside on ignition ≤0.1% 2g/ 8 00 ºC /5hrs
Odor & Taste Characteristic Sensory
Solubility S oluble in ethanol Visual
 Density  0.3~0.6g/ml  W/V
 Particle size  20~60mesh  Sieve
 PH  6-9  ChP
Melting point 9 6 .0ºC-99.0ºC C hP

Solubility 		Soluble in 96% ethanol and acetone, slightly soluble in chloroform, almost insoluble in water .
ChP
Color of  solution 1g dissolved in 96% ethanol must be equivalent to BY5 standard color .

  		ChP


HPLC identification 		The retention time of the main peak on the chromatogram of the solution should be consistent with the retention time of the main peak on the chromatogram of the Indole-3methanol standard solution.
ChP

UV  identification 		The UV absorption spectrum of the solution and the standard solution of hydrazine 3 methanol in the range of 220 to 380 nm should have the same maximum wavelength, minimum value and shoulder peak value.
UV



Chemical 		Heavy metals ≤10ppm Colorimetric   method
Arsenic(As) ≤ 1 .0 ppm Atomic Absorption
Lead(Pb) ≤ 3 .0 ppm Atomic Absorption
Cadmium(Cd) ≤1 .0 ppm Atomic Absorption
Mercury(Hg) ≤ 0.1 ppm Atomic Absorption
Chlorides ≤ 0.1% ChP
Sulphates ≤ 0.1% ChP
Ammonnium ≤ 0.1% ChP
Residual   Isopropyl alcohol


(
  		≤ 0.5% GC








 

Assay 		Indole-3-carbinol ≥9 8 . 0 0% HPLC
Any impurities ≤ 0.4% HPLC
Total impurit ies ≤ 1.0% HPLC




Microbial 		Total microbacterial ≤1000CFU/g ChP
Yeast &Mould ≤100CFU/g ChP
Escherichia Coli Negative /g ChP
Salmonella Negative /10g ChP
Pseudomonas Negative /g ChP
Stahylococcus aureus Negative /g ChP

Else
Packing 		Pack in paper-drums and two food grade poly bags inside. Net weight: 25kg/drum
Storage condition Store in a well closed dry place with constant low temperature  (2~8ºC)  and no direct sun light
Shelf life One  year when properly stored.

Description:
Indole 3 carbinol  (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale.  indole-3-carbinol is also available in a dietary supplement.  indole-3-carbinol is the subject of on-going Biomedical research into its possible anticarcinogenic, antioxidant, and antiatherogenic effects.


Indole 3 carbinol and Cancer:
Investigation of mechanisms by which consumption of indole-3-carbinol might influence cancer incidence focuses on its ability to alter estrogen metabolism and other cellular effects. Controlled studies have been performed on such animals as rats, mice, and rainbow trout, introducing various controlled levels of carcinogens, and levels of indole-3-carbinol into their daily diet.  Results showed dose-related decreases in tumor susceptibility due to indole-3-carbinol (inferred by decreases in aflatoxin-DNA binding).  The first direct evidence of pure anti-initiating activity by a natural anticarcinogen (indole-3-carbinol) found in human diet was claimed by Dashwood et al. in 1989.
 
Indole-3-carbinol induces a G1 growth arrest of human reproductive cancer cells.  This is potentially relevant to the prevention and treatment of cancer, as the G1 phase of cell growth occurs early in the cell life cycle, and, for most cells, is the major period of cell cycle during its lifespan.  The G1 phase is marked by synthesis of various enzymes that are required in the next ("S") phase, including those needed for DNA replication.
 
Overuse of indole-3-carbinol supplements in the hope of preventing cancer may be unwise, as the hormone balance should be tested (via simple blood test) before regular consumption.  Such caution is advised, due to its effect on estrogen levels (estrogen has a significant impact on brain function).
 
It promotes liver cancer in trout when it is combined with aflatoxin B1 and demotes metastasis .
 

Indole-3-Carbinol and Melanoma :

Indole-3-carbinol causes proliferation arrest and  apoptosis  in human  melanoma  cells. Kim  et al.  (2011) showed that the master regulator of melanoma biology,  microphthalmia-associated transcription factor  (MITF-M) was downregulated by indole-3-carbinol to induce apoptosis.Kundu  et al.  (2023) demonstrated that the anticancer property of indole-3-carbinol is driven by specific targeting of oncogenic pathways. In two different studies using xenografted mouse model of melanoma, they observed that subcutaneous injection of indole-3-carbinol could bring down tumor burden significantly. The underlying molecular mechanism of this anti-tumor effect was found to be by the specific inhibition of activity of oncogenic  BRAF V600E  in tumors that harbored the mutation. However, in tumors that expressed wild type BRAF, indole-3-carbinol did not cause any comparable antiproliferative effect. Additionally indole-3-carbinol did not cause antiproliferation even in normal epidermal melanocytes underscoring the specificity and selectivity of its action. Kundu  et al. [ citation needed ]  further showed that inhibition of BRAF V600E activity by indole-3-carbinol resulted in downregulation of MITF-M by downstream signaling which caused a G1  cell cycle  arrest leading to the observed antiproliferative effect.
In a second study Kundu  et al. [ citation needed ]  showed that in melanoma cells where  PTEN  is downregulated, indole-3-carbinol directly interacts with  NEDD4 1  to prevent PTEN ubiquitination and subsequent proteasomal degradation. This results in stabilization of PTEN and inhibition of proliferation by downstream  AKT  signaling. Overall scientific evidence shows that in melanoma, indole-3-carbinol specifically inhibits the two most commonly associated driver mutation signaling pathways to cause proliferation, a fact that can be used to design clinical trial to treat human patients with indole-3-carbinol in future.

Indole-3-Carbinol and Systemic lupus erythematosus :

Indole-3-carbinol can shift  estrogen  metabolism towards less estrogenic metabolites.  Systemic lupus erythematosus  (SLE, or lupus), an  autoimmune disease , is associated with estrogen. In a study using mice bred to develop lupus, indole-3-carbinol was fed to one group while another group was fed a standard mouse diet; the group fed the indole-3-carbinol diet lived longer and had fewer signs of disease.
Another study of lupus-prone mice with indole-3-carbinol defined the mechanism for the improvement of their disease to be due to sequential blocks in the development of  B  and  T cells  of these mice. The maturation arrests resulted in a fall in  autoantibody  production, thought to be a crucial component of lupus causation. In addition, I3C supplementation of the disease prone mice led to a normalization of their T cell function.
Women with lupus can manifest a metabolic response to indole-3-carbinol and might also benefit from its antiestrogenic effects. Clinical trials are currently underway to determine the efficacy of treating human patients with lupus using indole-3-carbinol.

Effect in recurrent respiratory papillomatosis

There is evidence suggesting that indole-3-carbinol may have an effect on  human papillomavirus -infected cells in both pediatrics and adult patients   Research is ongoing.

Application:
It is also called indol 3 Karbinol and has been used as Nutraceutical.
As a pharmaceutical intermediate, it has been used in the medicines field.


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Company Profile:
Indole-3-Carbinol Indole-3-Methanol
Indole-3-Carbinol Indole-3-Methanol

* Our History :
Jingxin Nutra Co., Ltd focus on the development of R&D, manufacturing and exporting  of nutrition & health ingredients  since 2012 . Our products are widely used in the fields of nutraceutical, dietary supplements, health food, beverage, cosmetic and pharmaceutical. 
We have been proudly serv ing  lots of contract manufacturers, brand customers and distributors in the global, and keep ing  very stable cooperation relationships with our customers.

* Main  Market :
Europe,  Russia, the Middle East , Asia, North America , South America etc.  more than 50  countries and regions.


*   Our Factory :
Our factory is constructed strictly in accordance with cGMP standard, it covers about 15000 square meters, with the clean workshop of 10000 square meters. .
We have both production lines of plant extracts and chemicals.

-> Production lines of Plant Extracts:
We  ha ve  100,000 grade fine drying and packaging workshop to ensure that the products are not polluted.
• Extraction: It has a variety of extraction equipment, including multifunctional extraction, continuous countercurrent extraction, etc., which can be applied to the extraction of various medicinal materials, processing 8,000 tons of  herb annually.
• Separation and refining: According to the product and process requirements, centrifugation, precision filtration, continuous ion exchange and other methods for separation and refining, to obtain high purity extract.
• Drying: With spray drying, freeze drying, vacuum drying, microwave drying .

-> Production lines of Chemicals :
It is  based on enzyme catalysis technology to produce synthethic chemicals.The production lines are equipped with R&D center, pilot plant, chemical reaction workshop, biological fermentation workshop, clean workshop etc and meets production quality management of cGMP, FSSC22000 and HACCP.



* Main Products:
Glutathione , L-Theanine, L-Melatonin, Alpha Lipoic Acid , β-Nicotinamide mononucleotide (NMN), Coenzyme Q10, L-Carnitine Base, S elachyl alcohol , Beta Glucan, 3,3'-diindolylmethane (DIM), Ascorbic Acid (Vitamin C), Vitamin B12, Sweeteners  etc.

Tongkat Ali Extract, Rutin, Fisetin, Milk Thistle Extract, Ginkgo Biloba Extract, Grape Seed Extract, Berberine HCL, Resveratrol, Monk Fruit Extract, Stevia Extract etc.

* Product s  Application :
Nutraceutical, dietary supplement, food additives, Beverage, cosmetics and feed additives  etc.

* C ertificate s :
ISO, KOSHER, HALAL

* Quality Control: 
We adhere to the orientation of 'Quality first"  and strictly control the whole product ion process meet cGMP standard.

Our quality inspection center is equipped with physical and chemical room , Ultraviolet analysis room, A tomic absorption   room, A tomic fluorescence room , Gas chromatography  room, High Performance Liquid Chromatography  room , balance room, Hi gh greenhouse, calibration room , bacteria examination room, R eagent room , stability laboratory, sample room and central laboratory.
The main testing capabilities include loss on drying , A sh, density, TLC, solubility, optical rotation, Transmittance, heavy metals, Lead, Arsenic, Calcium, Mercury, PH, protein, amino nitrogen, Assay, Purity, Solvent residue, Pesticide residue. Microbial detection includes detection of total Plate count , coliforms, yeasts and molds, salmonella, staphylococcus aureus   etc.

We strictly test all products from source to finished products to  ensure  it  meet customer's requirements.

* Our Service:
We provide r aw material ingredients, Pre mix blend and OEM are avaliable too .

We have decades of the experience in these fields, could offer considerate, timely and professional service.

If the quality do not complies with customer's specification, we will undertake the responsibility and give customer a full refund.

We hope to be your long-term partner for mutual benefit .
 

 

Pharmaceutical Intermediate

LEGALIS.IT, 2023