| Name | Doxylamine succinate |
| Synonyms | N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine succinate |
| Brand | FOUSI |
| Molecular Formula | C17H22N2O.C4H6O4 |
| Molecular Weight | 388.46 |
| CAS Registry Number | 562-10-7 |
| EINECS | 209-228-7 |
| Test Items | Specifications | Results |
| Appearance | White or almost white crystalline powder | Conform |
| Solubility | Very soluble in water, freelysoluble in alcohol | Conform |
|
Identification |
1) Melting range:103ºC-108ºC
2) Ultraviolet absorption: UVmax=262.0nm 3) Organic Nitrogenous Bases 4) Succinic acid melting range:184ºC-188ºC |
105ºC 262.0 nm Conform 186ºC-188ºC |
| Loss on drying | ≤0.5% | 0.3% |
| Residue on ignition | ≤0.1% | 0.1% |
| Related substances(GC) |
Total impurities≤2.0%
Single impurity≤1.0% |
1.9%
1.0% |
| Residual solvents |
Diethyl ether≤0.5%
Aceton e≤0.5% Iso-propyl ether≤0.5% Tolue ne≤0.1% |
0.4%
0.4% 0.4% 0.1% |
| Assay |
98.0%-101.0%
(Calculated on anhydrous substance) |
99.2% |
| Conclusion | Conform to the USP29 | |
Doxylamine succinate Silas more sensitive with antihistamines, fight the role and significant sedation. Doxylamine succinate is used to treat cardiovascular conditions.